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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED1
All Species:
26.97
Human Site:
S1289
Identified Species:
53.94
UniProt:
Q15648
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15648
NP_004765.2
1581
168478
S1289
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Chimpanzee
Pan troglodytes
XP_001172395
1581
168474
S1289
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537654
1583
168625
S1291
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q925J9
1575
167122
S1291
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Rat
Rattus norvegicus
NP_001127833
1567
166392
S1275
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521297
422
46589
K159
Y
N
L
P
G
D
N
K
L
K
T
K
M
Y
L
Chicken
Gallus gallus
XP_418125
1594
169410
S1300
S
S
Q
N
Q
H
G
S
S
K
G
K
S
P
S
Frog
Xenopus laevis
Q6INP8
1570
165663
L1280
C
G
G
V
S
Q
N
L
H
G
N
S
K
G
K
Zebra Danio
Brachydanio rerio
XP_700209
1694
176982
S1347
S
S
T
G
S
S
S
S
G
S
M
P
F
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VP05
1475
149513
S1212
Q
A
K
A
K
S
S
S
S
G
A
T
S
F
A
Honey Bee
Apis mellifera
XP_395879
1811
193227
S1515
N
I
L
L
P
A
L
S
S
G
S
T
H
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786427
2421
258175
K1735
D
K
V
E
K
V
E
K
S
E
K
T
E
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
98
N.A.
94.4
93.9
N.A.
24.4
87.6
72.5
56.4
N.A.
22
24.4
N.A.
25.7
Protein Similarity:
100
100
N.A.
98.9
N.A.
97.1
96.5
N.A.
25.7
93.5
81.7
69
N.A.
38.9
41.1
N.A.
38.5
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
13.3
100
0
26.6
N.A.
20
13.3
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
20
100
0
26.6
N.A.
46.6
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
0
9
0
0
0
0
9
0
0
0
9
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
9
0
0
9
0
0
9
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% F
% Gly:
0
9
9
9
9
0
50
0
9
25
50
0
0
9
0
% G
% His:
0
0
0
0
0
50
0
0
9
0
0
0
9
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
9
9
0
17
0
0
17
0
59
9
59
9
0
17
% K
% Leu:
0
0
17
9
0
0
9
9
9
0
0
0
0
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% M
% Asn:
9
9
0
50
0
0
17
0
0
0
9
0
0
0
0
% N
% Pro:
0
0
0
9
9
0
0
0
0
0
0
9
0
50
0
% P
% Gln:
9
0
50
0
50
9
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% R
% Ser:
59
59
0
0
17
17
17
75
75
9
9
9
59
9
59
% S
% Thr:
0
0
9
0
0
0
0
0
0
0
9
25
0
0
0
% T
% Val:
0
0
9
9
0
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _